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ProductsBack/Z-Leu-Leu-Nva-CHO [MG-115] [133407-86-0]
Chemical Structure
Chemical Structure
Chemical Structure

Z-Leu-Leu-Nva-CHO [MG-115] [133407-86-0]

Research Use Only
AG-CP3-0015
AdipoGen Life Sciences
CAS Number133407-86-0
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight461.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Z-Leu-Leu-Nva-CHO [MG-115] [133407-86-0]
  • Delivery Days Customer
    10
  • CAS Number
    133407-86-0
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C25H39N3O5
  • Molecular Weight
    461.6
  • Scientific Description
    Chemical. CAS: 133407-86-0. Formula: C25H39N3O5. MW: 461.6. Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway. Autophagy activator. - Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway. Autophagy activator.
  • SMILES
    [H]C(=O)[C@H](CCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids: J. Adams, et al.; Bioorg. Med. Chem. Lett. 17, 333 (1998)
  • Ubiquitination of E3 ubiquitin ligase TRIM5 alpha and its potential role: K. Yamauchi, et al.; FEBS J. 275, 1540 (2008)
  • Proteasome inhibition induces stress kinase dependent transport deficits-implications for Alzheimer's disease: L. Agholme, et al.; Mol. Cell Neurosci. 58, 29 (2014)