Z-VAD [162852-62-2]

TargetMol Chemicals

Z-VAD [162852-62-2]

9

Research Use Only

C20H27N3O8

437.44

Z-VAD is a competitive, irreversible, and broad-spectrum caspase inhibitor that inhibits all caspases except caspase-2, against which it is less effective. This compound reduces radiation-induced apoptosis and can induce autophagy and necrosis in radiation-treated xenografts of MDA-MB-231 and H460 in mice. When combined with radiation, Z-VAD significantly delays tumor growth and exhibits substantial anti-angiogenic effects in cancer xenografts.

C(OC(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)C)=O)C(C)C)=O)C1=CC=CC=C1

-20°C

12352200