Z640 an aPKC agonist. Z640 was further confirmed as a non-selective aPKC agonist that can activate the kinase activity of both PKCiota and PKCaeta. In the cell-based assay, Z640 was found to protect neuronal cell lines from amyloid-beta (Abeta) oligomer-induced cell death by reducing reactive oxygen species production and restore mitochondrial function. In addition, Z640 could reduce Abeta40 generation in a dose-dependent manner and shift amyloid precursor protein processing towards the non-amyloid pathway
