Zabedosertib

MedChem Express

Zabedosertib [1931994-81-8]

10

1931994-81-8

Research Use Only

98.14

C20H21F3N4O4S

470.47

Zabedosertib (BAY 1834845) is a selective, orally active IRAK4 inhibitor with immunomodulatory potential, IC50 is 3.55 nM. IRAK4 is a protein kinase involved in signaling innate immune responses from Toll-like receptors[1]. Zabedosertib exhibits anti-inflammatory property against IL-beta, LPS (HY-D1056) and Imiquimod (HY-B1080) induced inflammation[2].

O=C(C1=CC=CC(C(F)(F)F)=N1)NC2=CC3=CN(CCS(=O)(C)=O)N=C3C=C2C(C)(C)O

-20°C,2°C to 8°C

12352200