Zaldaride

MedChem Express

Zaldaride

9

Research Use Only

C26H28N4O2

428.53

Zaldaride (CGS-9343B free base) is a potent, orally active and selective inhibitor of calmodulin . Zaldaride inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC 50 of 3.3 nM [1] [2] . Zaldaride prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na + , Ca 2+ and K + currents in PC12 cells and inhibits nAChR [3] .

O=C1NC2=C(N1C3CCN(CC4(C)OCC5=C(N6C=CC=C64)C=CC=C5)CC3)C=CC=C2

12352200