More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/Zerumbone [471-05-6]
Chemical Structure
Chemical Structure
Chemical Structure

Zerumbone [471-05-6]

Research Use Only
AG-CN2-0004
AdipoGen Life Sciences
CAS Number471-05-6
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight218.3
Price on request
Packing Size
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Zerumbone [471-05-6]
  • Delivery Days Customer
    10
  • CAS Number
    471-05-6
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C15H22O
  • Molecular Weight
    218.3
  • Scientific Description
    Chemical. CAS: 471-05-6. Formula: C15H22O. MW: 218.3. Isolated from the underground parts of Curcuma zerumbet. Chemopreventive probe. Apoptosis inducer. Potent anti-tumor compound. Anti-inflammatory activity by downregulating COX-2 and iNOS expression via modulation of NF-kappaB activation. Antinociceptive. Probe to study chemokine receptors functioning. Potential therapeutic agent for osteoporosis and cancer-associated bone loss. Anti diabetic nephropathy - Chemopreventive probe. Apoptosis inducer. Potent anti-tumor compound. Sonic hedgehog signaling pathway inhibitor. Anti-inflammatory activity by downregulating COX-2 and iNOS expression via modulation of NF-kappaB activation. Antinociceptive. Potential therapeutic agent for osteoporosis and cancer-associated bone loss. Stimulator of the ATPase activity of Hsp90.
  • SMILES
    C\C1=C/CC(C)(C)\C=C\C(=O)\C(C)=C\CC1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet: T. Tanaka, et al.; Life Sci. 69, 1935 (2001)
  • Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. S. Yodkeeree, et al.; Cancer Res. 69, 6581 (2009)
  • Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells: S.I. Abdelwahab, et al.; Leuk. Res. 35, 268 (2010)
  • Antitumor effects of zerumbone from Zingiber zerumbet in P-388D1 cells in vitro and in vivo: G.C. Huang, et al.; Planta Med. 71, 219 (2005)
  • Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines: A. Murakami, et al.; Biofactors 21, 95 (2004)
  • Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice: M. R. Sulaiman, et al.; Fitoterapia 81, 855 (2010)
  • Preliminary analysis of the antinociceptive activity of zerumbone: M. R. Sulaiman, et al.; Fitoterapia 80, 230 (2009)
  • Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells: B. Sung, et al.; Cancer Res. 68, 8938 (2008)
  • Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice: B. Sung, et al.; Cancer Res. 69, 1477 (2009)
  • Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion: Y. Takada, et al.; Oncogene 24, 6957 (2005)