Zeteletinib

MedChem Express

Zeteletinib [2216753-97-6]

10

2216753-97-6

Research Use Only

99.06

C25H23F3N4O4

500.47

Zeteletinib (BOS-172738; DS-5010) is an orally active, selective RET kinase inhibitor with nanomolar potency against RET and >300-fold selectivity against VEGFR2. Zeteletinib shows exquisite potency for the wild type RET , RET V804M/L gatekeeper mutants, and the most common oncogenic RET mutation M918T . Zeteletinib has potent antitumor activity [1] [2] [3] .

O=C(CC1=CC=C(C2=CN=C3C=C(C(OC)=CC3=C2)OC)N=C1)NC4=CC(C(C)(C(F)(F)F)C)=NO4

-20°C,2°C to 8°C

12352200