Zidesamtinib

AbMole BioScience

Zidesamtinib

9

2739829-00-4

Chemical

Research Use Only

C22H22FN7O

419.45

Zidesamtinib is a potent, selective, orally active and blood-brain barrier permeable inhibitor of multiple ROS1 fusion and resistance mutations, with IC50 values of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively, and does not inhibit TRK.May be useful in studies related to non-small cell lung cancer and other solid tumors.

CC[N]1N=CC2=C1C3=CC(=C(N)N=C3)OC(C)C4=CC(=CC=C4C5=N[N](C)N=C5C2)F

12352200