ZINC05007751

MedChem Express

ZINC05007751 [591239-68-8]

10

591239-68-8

Research Use Only

98.47

C18H12N2O3

304.30

ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 microM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9[1].

N#CC(C1=O)=C(C)/C(C(N1)=O)=C/C2=CC=C(C3=CC=CC=C3)O2

2°C to 8°C

12352200