ZNF354A Polyclonal Antibody

Reddot Biotech

ZNF354A Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.5 mg/ml

Unconjugated

ZNF354A

zinc finger protein 354A

epididymis luminal protein 104; EZNF; HEL104; HKL1; KID1; KID-1; TCF17; transcription factor 17; zinc finger protein 354A; zinc finger protein eZNF

Rabbit

IgG

ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Kr√ppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.

Human, Mouse, Rat

-20°C

12352203