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ZNF451 Polyclonal Antibody

Research Use Only
RD266483A
Reddot Biotech
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetZNF451
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    ZNF451 Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID26036
  • Target name
    ZNF451
  • Target description
    zinc finger protein 451
  • Target synonyms
    coactivator for steroid receptors; COASTER; dJ417I1.1; E3 SUMO-protein ligase ZNF451; E3 SUMO-protein transferase ZNF451
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site Lys-11 (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at Lys-9. Plays a role in regulating the transcription of AR targets.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203