Zotarolimus [221877-54-9]

Biorbyt

Zotarolimus [221877-54-9]

16

221877-54-9

Research Use Only

C52H79N5O12

966.21

Zotarolimus (ABT-578, A 179578) is a semi-synthetic analogue of rapamycin, inhibits FKBP-12 binding with IC50 of 2.8 nM and shows less potent systemic immunosuppression than rapamycin.

CO[C@@H]1C(C)=CC=CC=C[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)C(C)=C[C@@H](C)C(=O)C[C@@H]([C@@H](C[C@@H]2CC[C@H](N3C=NN=N3)[C@H](OC)C2)C)OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@@]2(O)[C@@H](CC[C@H](O2)C1)C - c:23,t:4,6,8,&1:2,10,13,17,20,25,30,31,33,36,42,50,60,62,65 -

12352200