ZT-12-037-01

MedChem Express

ZT-12-037-01 [2328073-61-4]

5

2328073-61-4

Research Use Only

98.06

C21H31N5O2

385.50

ZT-12-037-01 is a STK19-targeted inhibitor, has a high-affinity interaction with STK19 protein and inhibits oncogenic NRAS-driven melanocyte malignant transformation. ZT-12-037-01 is an ATP -competitive inhibitor, inhibiting phosphorylation of NRAS (major isoform of Ras family) with an IC 50 of 24 nM [1] .

COC1=CC2=NC(NC3CC3)=NC(NC4CCN(C(C)C)CC4)=C2C=C1OC

-20°C,2°C to 8°C

12352200