1-Formyl-beta-carboline [20127-63-3]

MedChem Express

1-Formyl-beta-carboline [20127-63-3]

9

20127-63-3

Research Use Only

99.70

C12H8N2O

196.21

1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 microM, and its inhibition rate is more than 90% at a concentration of 20 microM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway[1].

C1=CC=C2C(=C1)C3=C(C(=NC=C3)C=O)N2

-20°C

12352200