1-Methyladenosine (Standard)

MedChem Express

1-Methyladenosine (Standard) [15763-06-1]

9

Research Use Only

1-Methyladenosine (Standard) is the analytical standard of 1-Methyladenosine. This product is intended for research and analytical applications. 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARdelta expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis [1] [2] [3] . In Vitro: Compared to surrounding tumor tissues, 1-methyladenosine methylation in RNA is aberrantly elevated in hepatocellular carcinoma (HCC) cell lines and liver cancer stem cells (CSCs). Methylated 1-methyladenosine can promote cholesterol synthesis and activate the Hedgehog signaling pathway by enhancing the translation of PPARdelta in liver CSCs, ultimately driving the self-renewal and tumorigenesis of liver cancer stem cells [3] .

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