1-Naphthohydroxamic acid

MedChem Express

1-Naphthohydroxamic acid [6953-61-3]

10

6953-61-3

Research Use Only

99.72

C11H9NO2

187.19

1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 microM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 microM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].

O=C(C1=C2C=CC=CC2=CC=C1)NO

-20°C,2°C to 8°C

12352200