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ProductsBack/10Z-Hymenialdisine [82005-12-7]
Chemical Structure
Chemical Structure
Chemical Structure

10Z-Hymenialdisine [82005-12-7]

Research Use Only
AG-CN2-0067
AdipoGen Life Sciences
CAS Number82005-12-7
DownloadMSDS
Product group Chemicals
Estimated Purity>97%
Molecular Weight324.1
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    10Z-Hymenialdisine
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    82005-12-7
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C11H10BrN5O2
  • Molecular Weight
    324.1
  • Scientific Description
    Chemical. CAS: 82005-12-7. Formula: C11H10BrN5O2. MW: 324.1. Isolated from sponge Axinella carteri. Insecticidal and cytotoxic. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines. ATP-competitive kinase inhibitor. Inhibits DNA damage checkpoint at G2, cyclin-dependent kinases CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p25, GSK-3beta and casein kinase 1 (CK1). Potent mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor. MARK (microtubule affinity-regulating kinase) inhibitor. - Insecticidal and cytotoxic [1]. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines [2, 3, 4, 9]. ATP-competitive kinase inhibitor. Inhibits DNA damage checkpoint at G2, cyclin-dependent kinases CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p25, GSK-3beta and casein kinase 1 (CK1) [5, 6]. Potent mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor [7]. MARK (microtubule affinity-regulating kinase) inhibitor [8].
  • SMILES
    NC1=NC(=O)\C(N1)=C1/CCNC(=O)C2=C1C=C(Br)N2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UN Number
    UN 2810
  • UNSPSC
    12352200

References

  • Bioactive alkaloids from the tropical marine sponge Axinella carteri: A. Supriyono, et al.; Z. Naturforsch. [C] 50, 669 (1995)
  • The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB: J.J. Breton & M.C. Chabot-Fletcher; J. Pharmacol. Exp. Ther. 282, 459 (1997)
  • Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine: A. Roshak, et al.; J. Pharmacol. Exp. Ther. 283, 955 (1997)
  • Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage/chondrocyte cultures by the natural product, hymenialdisine: A.M. Badger, et al.; J. Pharmacol. Exp. Ther. 290, 587 (1999)
  • Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent: L. Meijer, et al.; Chem. Biol. 7, 51 (2000)
  • Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine: D. Curman, et al.; J. Biol. Chem. 276, 17914 (2001)
  • Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002)
  • Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity: J. Biernat et al.; Mol. Biol. Cell. 13, 4013 (2002)
  • Inhibition of cytokine production by hymenialdisine derivatives: V. Sharma, et al.; J. Med. Chem. 47, 3700 (2004)