10Z-Hymenialdisine [82005-12-7]

AdipoGen Life Sciences

10Z-Hymenialdisine

10

6.1

82005-12-7

Research Use Only

>97%

Danger,Excepted quantity

C11H10BrN5O2

324.1

Chemical. CAS: 82005-12-7. Formula: C11H10BrN5O2. MW: 324.1. Isolated from sponge Axinella carteri. Insecticidal and cytotoxic. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines. ATP-competitive kinase inhibitor. Inhibits DNA damage checkpoint at G2, cyclin-dependent kinases CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p25, GSK-3beta and casein kinase 1 (CK1). Potent mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor. MARK (microtubule affinity-regulating kinase) inhibitor. - Insecticidal and cytotoxic [1]. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines [2, 3, 4, 9]. ATP-competitive kinase inhibitor. Inhibits DNA damage checkpoint at G2, cyclin-dependent kinases CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p25, GSK-3beta and casein kinase 1 (CK1) [5, 6]. Potent mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor [7]. MARK (microtubule affinity-regulating kinase) inhibitor [8].

NC1=NC(=O)\C(N1)=C1/CCNC(=O)C2=C1C=C(Br)N2

-20°C,2°C to 8°C

UN 2810

12352200