11R-VIVIT [592517-80-1]

TargetMol Chemicals

11R-VIVIT [592517-80-1]

16

592517-80-1

Chemical

Research Use Only

11R-VIVIT

C147H259N67O36S

3573.15

NFAT inhibitor. Inhibits LPS or LPS plus IFN-gamma-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable.

3 years

C([C@@H](NC(=O)[C@H]1N(C(CNC([C@@H](NC([C@@H](NC(CNC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)=O)=O)CCSC)=O)C)=O)=O)CCC1)CC2=CN=CN2)(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(=O)N4[C@H](C(N[C@@H](CC5=CN=CN5)C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)CCC(O)=O)=O)=O)CCC4)=O)[C@@H](C)O)=O)[C@H](CC)C)=O)C(C)C)=O)[C@H](CC)C)=O)[C@H](C)C)=O)CCC3

-20°C

12352200