1,2,3,6-Tetragalloylglucose [79886-50-3]

MedChem Express

1,2,3,6-Tetragalloylglucose [79886-50-3]

5

79886-50-3

Research Use Only

99.08

C34H28O22

788.57

1,2,3,6-Tetragalloylglucose (TEgG) is a competitive inhibitor of UDP-glucuronyltransferase UGT1A1, targeting the competitive substrate binding site of UGT1A1. 1,2,3,6-Tetragalloylglucose inhibits UGT1A1-mediated beta-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 microM and 4.31 microM, respectively, and binds to UGT1A1 with Ki of 3.55 microM. 1,2,3,6-Tetragalloylglucose also induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1,2,3,6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease[1][2][3].

O=C(C1=CC(O)=C(O)C(O)=C1)O[C@@H]2[C@H]([C@@H]([C@@H](COC(C3=CC(O)=C(O)C(O)=C3)=O)O[C@H]2OC(C4=CC(O)=C(O)C(O)=C4)=O)O)OC(C5=CC(O)=C(O)C(O)=C5)=O

2°C to 8°C

12131703