12R-LOX-IN-1

Biorbyt

12R-LOX-IN-1

10

Research Use Only

98.00%

C15H11NO2

237.25

12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 microM, is an inhibitor of 12R-LOX. It suppresses hyperproliferation and colony formation in Imiquimod-induced psoriatic keratinocytes, and reduces levels of reactive oxygen species, Ki67, IL-17A, TNF-alpha, and IL-6. This compound has utility in antipsoriatic research [1].

OC=1C=CC=2N=C(C=CC2C1)C=3C=CC=CC3O

-20°C

12352200