1,3-PBIT (dihydrobromide)

MedChem Express

1,3-PBIT (dihydrobromide)

5

Research Use Only

C12H20Br2N4S2

444.25

1,3-PBIT is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 microM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.

NC(SCCC1=CC(CCSC(N)=N)=CC=C1)=N.Br.Br

12352200