13,14-dihydro-16,16-difluoro Prostaglandin E1

Biorbyt

13,14-dihydro-16,16-difluoro Prostaglandin E1

10

475992-30-4

Research Use Only

98.00%

C20H34F2O5

392.484

Prostaglandin E1 (PGE1), synthesized through cyclooxygenase-mediated metabolism of dihomo-gamma-linolenic acid (DGLA), functions by inhibiting platelet aggregation (IC50= 40 nM) and enhancing vasodilation. Its analog, 13,14-dihydro-16,16-difluoro PGE1, and the metabolite, 13,14-dihydro PGE1, both retain similar anti-aggregatory properties to the original compound. The inclusion of two electron-withdrawing fluorine atoms in 13,14-dihydro-16,16-difluoro PGE1 is believed to increase molecular stability and potentially extend bioavailability by resisting hydrolytic degradation.

CCCCC(F)(F)[C@H](O)CC[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O

-20°C

12352200