Bio-Connect

14-3-3 sigma antibody

GTX100289
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetSFN
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Overview

  • Supplier
    GeneTex
  • Product Name
    14-3-3 sigma antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2810
  • Target name
    SFN
  • Target description
    stratifin
  • Target synonyms
    14-3-3 protein sigma; epithelial cell marker protein 1; YWHAS
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP31947
  • Protein Name
    14-3-3 protein sigma
  • Scientific Description
    Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. p53-regulated inhibitor of G2/M progression.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild-type TP53 colon and gastric cancer cells with aberrant KRAS signaling. Wang X et al., 2021 Jul, Oncol Lett
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  • TRIM25 is associated with cisplatin resistance in non-small-cell lung carcinoma A549 cell line via downregulation of 14-3-3sigma. Qin X et al., 2017 Nov 4, Biochem Biophys Res Commun
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  • Epstein-Barr virus (EBV) Rta-mediated EBV and Kaposis sarcoma-associated herpesvirus lytic reactivations in 293 cells. Chen YJ et al., 2011 Mar 10, PLoS One
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