1,4-DPCA [331830-20-7]

MedChem Express

1,4-DPCA [331830-20-7]

10

331830-20-7

Research Use Only

98.36

C13H8N2O3

240.21

1,4-DPCA, a potent prolyl-4-hydroxylase inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC50 of 2.4 microM. 1,4-DPCA inhibits prolyl-4-hydroxylases alpha isoforms stabilizes HIF-1alpha protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC50 of 60 microM[1][2].

O=C(C1=CN=C2C3=NC=CC=C3C=CC2C1=O)O

-20°C,2°C to 8°C

12352200