1400W (Dihydrochloride) (Standard) [214358-33-5]
HY-18731R
CAS Number214358-33-5
Product group Chemicals
Molecular Weight250.17
Overview
- SupplierMedChem Express
- Product Name1400W (Dihydrochloride) (Standard) [214358-33-5]
- Delivery Days Customer5
- CAS Number214358-33-5
- Category SupplierCHEMICAL,detergents_surfactants
- CertificationResearch Use Only
- Molecular Weight250.17
- Scientific Description1400W (Dihydrochloride) (Standard) is the analytical standard of 1400W (Dihydrochloride). This product is intended for research and analytical applications. 1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation[1][2].
- SMILESCC(NCC1=CC=CC(CN)=C1)=N.[H]Cl.[H]Cl
- UNSPSC12352100