15(R)-15-Methyl Prostaglandin F2alpha

MedChem Express

15(R)-15-Methyl Prostaglandin F2alpha [35864-81-4]

5

35864-81-4

Research Use Only

C21H36O5

368.51

15(R)-15-Methyl Prostaglandin F2alpha (15(R)-Carboprost; 15(R)-15-methyl PGF2alpha) is a metabolically stable analog of PGF2alpha. 15(R)-15-Methyl Prostaglandin F2alpha is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-Methyl Prostaglandin F2alpha converts it into the active 15(S)-isomer. The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.

CCCCC[C@@](C)(O)/C=C/[C@@H]1[C@H]([C@@H](O)C[C@H]1O)C/C=C\CCCC(O)=O

12352200