15(R)-17-phenyl trinor Prostaglandin F2alpha [41639-71-8]

TargetMol Chemicals

15(R)-17-phenyl trinor Prostaglandin F2alpha [41639-71-8]

16

41639-71-8

Chemical

Research Use Only

15(R)-17-phenyl trinor Prostaglandin F2alfa

C23H32O5

388.5

17-phenyl trinor Prostaglandin F2alpha N-ethyl amide (17-phenyl trinor PGF2alpha) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2alpha ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2alpha ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 microg/cornea/24 hours. The free acid, 17-phenyl trinor PGF2alpha, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2alpha is the 15-epi, or unnatural isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity

3 years

C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@@H](CCC2=CC=CC=C2)O)[C@H](O)C[C@@H]1O

-20°C

12352200