17-(Allylamino-d5) Geldanamycin

Toronto Research Chemicals

17-(Allylamino-d5) Geldanamycin

15

Research Use Only

yes

C31 D5 H38 N3 O8

590.719

Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.

45900

[2H]C(=C([2H])C([2H])([2H])NC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)\C=C(/C)\[C@H](OC(=O)N)[C@@H](OC)\C=C/C=C(\C)/C(=O)NC(=CC1=O)C2=O)[2H]

-20°C

12161600