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17-Allylaminogeldanamycin [75747-14-7]

Research Use Only
A0025
LKT Laboratories
Product group Chemicals
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    17-Allylaminogeldanamycin [75747-14-7]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Scientific Description
    Geldanamycin derivative; HSP90 inhibitor.; 17-(Allylamino)-17-desmethoxy-geldanamycin, allylaminogeldanamycin, 17-AAG, telatinib.
  • UNSPSC
    12352200

References

  • Thangjam GS, Dimitropoulou C, Joshi AD, et al. Novel mechanism of attenuation of LPS-induced NF-kappaB activation by the heat shock protein 90 inhibitor, 17-N-allylamino-17-demethoxygeldanamycin, in human lung microvascular endothelial cells. Am J Respir Cell Mol Biol. 2014 May;50(5):942-52. PMID: 24303801. Powers MV, Valenti M, Miranda S, et al. Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX. Oncotarget. 2013 Nov;4(11):1963-75. PMID: 24185264. Evers DL, Chao CF, Zhang Z, et al. 17-allylamino-17-(demethoxy)geldanamycin (17-AAG) is a potent and effective inhibitor of human cytomegalovirus replication in primary fibroblast cells. Arch Virol. 2012 Oct;157(10):1971-4. PMID: 22711259. Gloesenkamp C, Nitzsche B, Lim AR, et al. Heat shock protein 90 is a promising target for effective growth inhibition of gastrointestinal neuroendocrine tumors. Int J Oncol. 2012 May;40(5):1659-67. PMID: 22246317.