17-phenyl trinor Prostaglandin F2alpha isopropyl ester [130209-76-6]

TargetMol Chemicals

17-phenyl trinor Prostaglandin F2alpha isopropyl ester [130209-76-6]

16

130209-76-6

Research Use Only

17-phenyl trinor Prostaglandin F2alfa isopropyl ester

C26H38O5

430.58

17-phenyl trinor PGF2alpha N-ethyl amide is an F-series prostaglandin analog approved as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted into the active free acid more slowly than analogous prostaglandin ester prodrugs like latanoprost. This product is the isopropyl ester of the free acid prostaglandin corresponding to Bimatoprost. The free acid, 17-phenyl trinor PGF2alpha, is a potent FP receptor agonist, and in human and animal glaucoma models, FP receptor agonist activity closely correlates with intraocular hypotensive activity. The 17-phenyl trinor PGF2alpha isopropyl ester derivative was examined for IOP-lowering activity during latanoprosts development and, at a dose of 3 microg/eye in monkeys, was the most potent analog, reducing IOP by 1.3 mm Hg more than latanoprost, though it was also significantly more irritating to the eye.

3 years

C(/C=C\CCCC(OC(C)C)=O)[C@@H]1[C@@H](/C=C/[C@H](CCC2=CC=CC=C2)O)[C@H](O)C[C@@H]1O

-20°C

12352200