17beta-Hydroxywortmannin [58053-83-1]

MedChem Express

17beta-Hydroxywortmannin [58053-83-1]

5

58053-83-1

Research Use Only

C23H26O8

430.45

17beta-Hydroxywortmannin (Wortmannin-17beta-ol) is an orally active inhibitor for phosphatidylinositol-3-kinase (PI-3-kinase) with an IC50 of 0.5 nM, suppresses the osteoclast resorption with an IC50 of 10 nM[1]. 17beta-Hydroxywortmannin exhibits antitumor activity[2].

C[C@@]12C3=C(C(C4=C1C(C(O[C@@H]2COC)=O)=CO4)=O)[C@@]5([H])[C@](C[C@H]3OC(C)=O)([C@H](CC5)O)C

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