(1E)-CFI-400437 (dihydrochloride)

MedChem Express

(1E)-CFI-400437 (dihydrochloride) [1247000-76-5]

10

1247000-76-5

Research Use Only

98.08

C29H30Cl2N6O2

565.49

(1E)-CFI-400437 dihydrochloride is a potent PLK4 ( IC 50 = 0.6 nM) inhibitor and selective against other members of the PLK family (>10 microM). (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR and FLT-3 with IC 50 s of 0.37, 0.21, 0.48, and 0.18 microM, respectively. Antiproliferative activity [1] .

Cl[H].Cl[H].COC1=CC(/C2=C/C3=CC4=C(C(/C=C/C5=CC=C(N=C5)N6CCN(CC6)C)=NN4)C=C3)=C(C=C1)NC2=O

2°C to 8°C

12352200