(1R,2R)-Calhex 231 (hydrochloride)

MedChem Express

(1R,2R)-Calhex 231 (hydrochloride)

14

Research Use Only

99.07

C25H28Cl2N2O

443.41

(1R,2R)-Calhex 231 hydrochloride is the isomer of Calhex 231 hydrochloride (HY-103320A), and can be used as an experimental control. Calhex 231 hydrochloride is a CaSR inhibitor via negative allosteric modulation. Calhex 231 hydrochloride blocks Ca 2+ -induced accumulation of [ 3 H]inositol phosphate with an IC 50 of 0.39 microM in HEK293 cells. Calhex 231 hydrochloride has the potential for diabetic cardiomyopathy (DCM) treatment [1] [2] .

O=C(N[C@H]1[C@H](N[C@@H](C2=C3C=CC=CC3=CC=C2)C)CCCC1)C4=CC=C(Cl)C=C4.[H]Cl

-20°C

12352200