(1S,2R)-Alicapistat [2221010-57-5]

MedChem Express

(1S,2R)-Alicapistat [2221010-57-5]

10

2221010-57-5

Research Use Only

98.0

C25H27N3O4

433.50

(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimers disease (AD)[1]. (1S,2R)-Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC50 value of 395 nM[2].

O=C1N([C@H](CC1)C(N[C@H](C(C(NC2CC2)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4

-20°C,2°C to 8°C

12352200