(+/-)2-(14,15-Epoxyeicosatrienoyl) glycerol [848667-56-1]

MedChem Express

(+/-)2-(14,15-Epoxyeicosatrienoyl) glycerol [848667-56-1]

5

848667-56-1

Research Use Only

C23H38O5

394.54

(+/-)2-(14,15-Epoxyeicosatrienoyl) glycerol ((+/-)2-14,15-EG) is a novel CYP450 metabolite of 2-Arachidonoyl glycerol (2-AG) in the kidney. (+/-)2-(14,15-Epoxyeicosatrienoyl) glycerol is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells. (+/-)2-(14,15-Epoxyeicosatrienoyl) glycerol activates the metalloprotease ADAM17, which cleaves proTGF-alpha and releases TGF-alpha as a ligand that initiates the EGFR-ERK signalling pathway[1].

OCC(CO)OC(CCC/C=C\C/C=C\C/C=C\CC1C(O1)CCCCC)=O

41115811