2-APQC

MedChem Express

2-APQC [500271-63-6]

5

Research Use Only

99.70

C23H24FN5O

405.47

2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (Kd=2.756 microM), antagonizes Isoproterenol/ISO (HY-B0468)-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-beta/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure[1].

CCCCCNC(C1=C(N(C2=NC3=C(N=C21)C=CC=C3)CC4=CC=C(C=C4)F)N)=O

-20°C

12352200