2-Azido-2-deoxycytidine [51034-68-5]

MedChem Express

2-Azido-2-deoxycytidine [51034-68-5]

5

51034-68-5

Research Use Only

98.78

C9H12N6O4

268.23

2-Azido-2-deoxycytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2-Azido-2-deoxycytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. 2-Azido-2-deoxycytidine is an azidonucleoside,and it should be phosphorylated twice to become an inhibitor of the nucleotide reductase.

OC[C@@H]1[C@@H](O)[C@@H](N=[N+]=[N-])[C@H](N2C(N=C(N)C=C2)=O)O1

-20°C,2°C to 8°C

41115811