2-Bromo-4-hydroxyacetophenone [2491-38-5]

TargetMol Chemicals

2-Bromo-4-hydroxyacetophenone [2491-38-5]

9

2491-38-5

Chemical

Research Use Only

2-Bromo-4'-hydroxyacetophenone

99.07%

C8H7BrO2

215.04

2-Bromo-4-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(deltaSH2)) with a Ki value of 43 microM and PTP1B with a Ki value of 42 microM [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2].

3 years

OC1=CC=C(C=C1)C(=O)CBr

-20°C

12352200