2-(Cyclohexylmethyl)-plumbagin [3033734-59-4]
HY-169830
Molecular Weight270.32
Product group Chemicals
Overview
- SupplierMedChem Express
- Product Name2-(Cyclohexylmethyl)-plumbagin [3033734-59-4]
- Delivery Days Customer5
- CertificationResearch Use Only
- Molecular FormulaC17H18O3
- Molecular Weight270.32
- Scientific Description2-(Cyclohexylmethyl)-plumbagin is a derivative of the naphthoquinone compound Plumbagin (HY-N1497). Under nutrient-deprived conditions, 2-(Cyclohexylmethyl)-plumbagin selectively exhibits cytotoxicity against PANC-1 human pancreatic cancer cells (PC50 = 0.11 microM) and reduces the phosphorylation of Akt and mTOR in PANC-1 cells. 2-(Cyclohexylmethyl)-plumbagin also induces apoptosis (Apoptosis) in PANC-1 cells at a concentration of 1 microM. Additionally, 2-(Cyclohexylmethyl)-plumbagin reduces tumor volume and weight in a xenograft MiaPaCa-2 pancreatic cancer mouse model[1].
- SMILESO=C1C=C(CC2CCCCC2)C(C3=C1C(O)=CC=C3)=O
- UNSPSC12352200