2-(cyclohexylmethyl)-Plumbagin

TargetMol Chemicals

2-(cyclohexylmethyl)-Plumbagin

44

Research Use Only

2-(cyclohexylmethyl)-Plumbagin

C17H18O3

270.3

2-(Cyclohexylmethyl)-Plumbagin, a naphthoquinone derivative, exhibits selective cytotoxicity towards PANC-1 human pancreatic cancer cells under nutrient-deprived conditions-a situation akin to the pancreatic cancer tumor microenvironment-over those in nutrient-rich settings, with PC50 values of 0.11 and 47.2 microM, respectively. At a 1 microM concentration, it triggers apoptosis in PANC-1 cells. Furthermore, this compound specifically inhibits the phosphorylation of Akt and mammalian target of rapamycin (mTOR) in PANC-1 cells under nutrient scarcity. In a MiaPaCa-2 pancreatic cancer mouse xenograft model, it significantly reduces tumor volume and weight when administered at 50 and 250 microg/animal dosages five times weekly.

3 years

OC1=C2C(C(C(CC3CCCCC3)=CC2=O)=O)=CC=C1

-20°C

12352200