2-Deoxy-2-fluoroadenosine [64183-27-3]

MedChem Express

2-Deoxy-2-fluoroadenosine [64183-27-3]

10

64183-27-3

Research Use Only

99.71

C10H12FN5O3

269.24

2-Deoxy-2-fluoroadenosine can be used for the synthesis of 2-Deoxy-2-fluoro-modified oligonucleotides hybridized with RNA. 2-Deoxy-2-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2-Deoxy-2-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP[1].

OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(N=CN=C3N)=C3N=C2)O1

2°C to 8°C

41115811