2-Deoxyuridine (Standard)

MedChem Express

2-Deoxyuridine (Standard) [951-78-0]

999

951-78-0

Research Use Only

C9H12N2O5

228.20

2-Deoxyuridine (Standard) is the analytical standard of 2-Deoxyuridine. This product is intended for research and analytical applications. 2-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2-deoxyuridine, EdU (HY-118411). 2-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Abeta25-35-induced brain injury, which is promising for research of Alzheimers disease (AD)[1][2][3]. In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine[2]. Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min[2]. In Vivo:2-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain[3]. 2-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Abeta25-35-induced mice model[3].

O=C(N1)N([C@H]2C[C@H](O)[C@@H](CO)O2)C=CC1=O

12352200