2-Guanidinobezimidazole [5418-95-1]
HY-W158030
CAS Number5418-95-1
Product group Chemicals
Estimated Purity95.74
Molecular Weight175.19
Overview
- SupplierMedChem Express
- Product Name2-Guanidinobezimidazole [5418-95-1]
- Delivery Days Customer5
- CAS Number5418-95-1
- CertificationResearch Use Only
- Estimated Purity95.74
- Molecular FormulaC8H9N5
- Molecular Weight175.19
- Scientific Description2-Guanidinobezimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 microM to His-GFP-NLRP3. 2-Guanidinobezimidazole binds directly to the LRR domain of NLRP3, promoting inflammasome assembly and activation. 2-Guanidinobezimidazole promotes anti-tumor immunity, inhibits tumor growth, and overcome immune checkpoint blockade (ICB) resistance[1].
- SMILESN/C(N)=N/C1=NC2=CC=CC=C2N1
- Storage Instruction2°C to 8°C
- UNSPSC12352200