2-MeS-ADP (trisodium) [475193-31-8]

MedChem Express

2-MeS-ADP (trisodium) [475193-31-8]

5

475193-31-8

Research Use Only

10 mM

99.90

C11H14N5Na3O10P2S

539.24

2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1[1][2][3].

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(SC)N=C3N)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O[Na])=O

-20°C

12352200