2-O-(3-Azidopropyl)-5-azacytidine

MedChem Express

2-O-(3-Azidopropyl)-5-azacytidine

10

Research Use Only

C10H15N7O5

313.27

2-O-(3-Azidopropyl)-5-azacytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2-O-(3-Azidopropyl)-5-azacytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

OC[C@@H]1[C@@H](O)[C@@H](OCCN=[N+]=[N-])[C@H](N2C=NC(N)=NC2=O)O1

41115811