2-O-Acetyl-3-azido-5-O-(4-methylbenzoyl)-3-deoxyuridine [256485-42-4]

MedChem Express

2-O-Acetyl-3-azido-5-O-(4-methylbenzoyl)-3-deoxyuridine [256485-42-4]

10

256485-42-4

Research Use Only

C19H19N5O7

429.38

2-O-Acetyl-3-azido-5-O-(4-methylbenzoyl)-3-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2-O-Acetyl-3-azido-5-O-(4-methylbenzoyl)-3-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

O=C(C1=CC=C(C)C=C1)OC[C@@H]2[C@@H](N=[N+]=[N-])[C@@H](OC(C)=O)[C@H](N3C(NC(C=C3)=O)=O)O2

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