22-(4-py)-JA [1178895-15-2]

MedChem Express

22-(4-py)-JA [1178895-15-2]

14

1178895-15-2

Research Use Only

C32H30N4O8

598.60

22-(4-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF). 22-(4-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC)[1].

O=C(C1=C(C2=O)C[C@@]3([H])[C@H](C#N)N4[C@@H](COC(C5=CC=NC=C5)=O)C(C(C(OC)=C(C)C6=O)=O)=C6C[C@@]4([H])[C@@]([H])1N3C)C(OC)=C2C

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