2,5-Dimethyl-celecoxib [457639-26-8] [457639-26-8]
BS-75508C
CAS Number457639-26-8
Product group Chemicals
Estimated Purity>99%
Molecular Weight395.4
Overview
- SupplierBioss
- Product Name2,5-Dimethyl-celecoxib [457639-26-8] [457639-26-8]
- Delivery Days Customer16
- CAS Number457639-26-8
- CertificationResearch Use Only
- ConjugateUnconjugated
- Estimated Purity>99%
- Molecular FormulaC18H16F3N3O2S
- Molecular Weight395.4
- Scientific DescriptionClose structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib, that lacks COX-2 inhibitory function. Anti-proliferative, anti-tumorigenic and anti-angiogenic. Potent apoptosis inducer in many cancer cell lines. Down-regulates the expression of survivin, cyclins, MMPs and inhibits cyclin-dependent kinase activity. Modulates PDK-1, AKT, GSK3beta, p70 S6K, PKA and MAPKAP-K1alpha. Reduces phosphorylation of ERK1/2 but not AKT T-308 or AKT S-473. Increases intracellular free calcium levels and potently triggers the endoplasmatic reticulum stress response (ESR), activating ER stress-associated proteins GRP78/BiP, CHOP/GADD153 and caspase-4.
- SMILESCC1=CC=C(C)C(=C1)C1=CC(=NN1C1=CC=C(C=C1)S(N)(=O)=O)C(F)(F)F
- Storage Instruction-20°C
- UNSPSC12161509