2,5-Dimethyl-celecoxib [457639-26-8]

AdipoGen Life Sciences

2,5-Dimethyl-celecoxib

10

6.1

457639-26-8

Research Use Only

>99%

Danger,Excepted quantity

C18H16F3N3O2S

395.4

Chemical. CAS: 457639-26-8. Formula: C18H16F3N3O2S. MW: 395.4. Close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib, that lacks COX-2 inhibitory function. Anti-proliferative, anti-tumorigenic and anti-angiogenic. Potent apoptosis inducer in many cancer cell lines. Down-regulates the expression of survivin, cyclins, MMPs and inhibits cyclin-dependent kinase activity. Modulates PDK-1, AKT, GSK3beta, p70 S6K, PKA and MAPKAP-K1alpha. Reduces phosphorylation of ERK1/2 but not AKT T-308 or AKT S-473. Increases intracellular free calcium levels and potently triggers the endoplasmatic reticulum stress response (ESR), activating ER stress-associated proteins GRP78/BiP, CHOP/GADD153 and caspase-4. - Close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib, that lacks COX-2 inhibitory function. Anti-proliferative, anti-tumorigenic and anti-angiogenic. Potent apoptosis inducer in many cancer cell lines. Down-regulates the expression of survivin, cyclins, MMPs and inhibits cyclin-dependent kinase activity. Modulates PDK-1, AKT, GSK3beta, p70 S6K, PKA and MAPKAP-K1alpha. Reduces phosphorylation of ERK1/2 but not AKT T-308 or AKT S-473. Increases intracellular free calcium levels and potently triggers the endoplasmatic reticulum stress response (ESR), activating ER stress-associated proteins GRP78/BiP, CHOP/GADD153 and caspase-4.

CC1=CC=C(C)C(=C1)C1=CC(=NN1C1=CC=C(C=C1)S(N)(=O)=O)C(F)(F)F

-20°C,2°C to 8°C

UN 2811

12352200