2,5-Dimethylcelecoxib

MedChem Express

2,5-Dimethylcelecoxib [457639-26-8]

5

457639-26-8

Research Use Only

99.57

C18H16F3N3O2S

395.40

2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the Wnt/beta-catenin signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/beta-catenin target gene products cyclin D1 and survivin [1] .

O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC(C)=CC=C3C)C=C1)(N)=O

2°C to 8°C

12352200